The Impact of Hemodialysis on Serum Prolactin and Testoesrone Level in CKD Male Patients

This study was conducted to assess the effect of hemodialysis (HD) on prolactin and testosterone level and their relations with study variables in chronic kidney disease (CKD) male patients. In a crosssectional study carried out in 80 males aged range from (22 to 80 years old), timed pre and post-HD samples were collected. Serum prolactin, testosterone, urea and creatinine were measured by using TOSOH® Bioscience full automated immunoassay analyzer AIA-360 and Mindary BS-200. Paired t-test found that mean testosterone, urea and creatinine level obtained after HD significantly lower p-value (0.000, 0.000 and 0.000) respectively, while insignificant difference was observed in mean prolactin concentration p-value 0.408. Interestingly change in prolactin after HD had a significant correlation with testosterone level (r = -0.280, pvalue 0.042). Present study has shown positive correlation of creatinine with urea and BMI changes after HD (r=0.568, p-value 0.000 and r=0.276, p-value 0.042) respectively, whereas no correlation observed with other study variables. Overall HD causes marked decrease in testosterone and slightly increase in prolactin level, so is contributing factor for the development of hypogonadism, gynecomastia, impotence and loss of libido on regular HD male patients.